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汤富酬

科普小知识2022-10-03 21:48:11
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汤富酬,男,1998年及2003年分别获北京大学生物学专业理学学士、博士学位。2004年-2010年在英国剑桥大学Gurdon研究所做博士后研究工作,现任北京大学生物动态光学成像中心(BIOPIC中心)研究员、清华大学-北京大学生命科学联合中心研究员、北京大学未来基因诊断高精尖创新中心研究员。2016年8月获国家杰出青年科学基金资助,2016年11月获第九届谈家桢生命科学创新奖。

1、人物简历

教育经历

1994-1998 本科,遗传学,北京大学。

1998-2003 博士,细胞生物学,北京大学。

工作经历

2004-2010 英国剑桥大学Gurdon研究所,博士后。

2010-现在 研究员,北京大学生命科学学院生物动态光学成像中心。

2015-现在  研究员,北大-清华生命科学联合中心。

2017-现在  教授,北京大学生命科学学院生物动态光学成像中心。

2、荣誉奖励

2014年度中国科学十大进展(“利用极体高通量测序结果精确推演出母源基因组信息”)。

2015年度中国科学十大进展(“揭示人类原始生殖细胞基因表达与表观遗传调控特征”)。

2015年度中国生命科学领域十大进展。

3、杂志

2014-2017  《ScienceBulletin》(《科学通报》英文版)编委(EditorialBoardMember)。

2015-至今  《GenomeBiology》编委(EditorialBoardMember)。

2016-至今  《OpenBiology》编委(EditorialBoardMember)。

4、科研领域

具有自我更新能力和分化潜能的干细胞是哺乳动物胚胎发育过程中以及成体中的关键类型的细胞,对各种干细胞进行深入研究是理解哺乳动物发育、生长机制的关键,也是将干细胞应用于临床再生医学、治疗人类疾病的前提。本实验室主要围绕人类早期胚胎发育研究多能干细胞的自我更新和多能性调控的分子机理,特别是表观遗传学调控机理,以及相关的早期生殖细胞发育过程中的表观遗传学重编程机理。利用我们发展的单细胞功能基因组学分析技术(单细胞转录组测序技术、单细胞DNA甲基化组测序技术、单细胞染色质状态组测序技术、单细胞多组学平行测序技术等),以及基因编辑技术、染色质免疫共沉淀-高通量测序技术、小鼠胚胎显微操作技术、以及人类胚胎干细胞体外定向分化等技术在单细胞和单碱基分辨率深入分析人类早期胚胎、生殖系细胞、以及多能性干细胞中基因表达网络的表观遗传学调控机理。

5、代表性论文

1.ZhuP,GuoH,RenY,HouY,DongJ,LiR,LianY,FanX,HuB,GaoY,WangX,WeiY,LiuP,YanJ,RenX,YuanP,YuanY,YanZ,WenL,YanL*,QiaoJ*,TangFuchou*.Single-cellDNAMethylomeSequencingofHumanPreimplantationEmbryos.NatureGenetics,2018,50:12-19(*:Co-correspondingauthors).

2.YangX,HuB,HouY,QiaoY*,WangR,ChenY,QianY,FengS,ChenJ,LiuC,PengG,TangFuchou*,JingN*.SilencingofdevelopmentalgenesbyH3K27me3andDNAmethylationreflectsthediscrepantplasticityofembryonicandextraembryoniclineages.CellResearch,2018,doi:10.1038/s41422-018-0010-1(*:Co-correspondingauthors).

3.WangS,HuB,DingZ,DangY,WuJ,LiD,LiuX,XiaoB,ZhangW,RenR,LeiJ,HuH,ChenC,ChanP,LiD,QuJ*,TangFuchou*,LiuGH*.ATF6safeguardsorganellehomeostasisandcellularaginginhumanmesenchymalstemcells.CellDiscovery,2018,4:2(*:Co-correspondingauthors).

4.WenL*&TangFuchou*.Singlecellepigenomesequencingtechnologies.MolecularAspectsofMedicine,2018,59:62-69(Review)(*:Co-correspondingauthors).

5.LiuJ,LiuW,YangL,WuQ,ZhangH,FangA,LiL,XuX,SunL,ZhangJ*,TangFuchou*,WangX*.ThePrimate-SpecificGeneTMEM14BMarksOuterRadialGliaCellsandPromotesCorticalExpansionandFolding.CellStemCell,2017,21:635-649(*:Co-correspondingauthors).

6.YangJ,LiJ,SuzukiK,LiuX,WuJ,ZhangW,RenR,ZhangW,ChanP,IzpisuaBelmonteJC,QuJ*,TangFuchou*,LiuGH*.Geneticenhancementinculturedhumanadultstemcellsconferredbyasinglenucleotiderecoding.CellResearch,2017,27:1178-1181(*:Co-correspondingauthors).

7.GuoF*,LiL,LiJ,WuX,HuB,ZhuP,WenL,TangFuchou*.Single-cellmulti-omicssequencingofmouseearlyembryosandembryonicstemcells.CellResearch,2017,27:967-988(*:Co-correspondingauthors).

8.LiL,DongJ,YanL,YongJ,LiuX,HuY,FanX,WuX,GuoH,WangX,ZhuX,LiR,YanJ,WeiY,ZhaoY,WangW,RenY,YuanP,YanZ,HuB,GuoF,WenL,TangFuchou*,QiaoJ*.Single-CellRNA-SeqAnalysisMapsDevelopmentofHumanGermlineCellsandGonadalNicheInteractions.CellStemCell,2017,20:858-873(*:Co-correspondingauthors).

9.ZhuC,GaoY,GuoH,XiaB,SongJ,WuX,ZengH,KeeK,TangFuchou*,YiC*.Single-Cell5-FormylcytosineLandscapesofMammalianEarlyEmbryosandESCsatSingle-BaseResolution.CellStemCell,2017,20:720-731(*:Co-correspondingauthors).

10.GuoH,HuB,YanL,YongJ,WuY,GaoY,GuoF,HouY,FanX,DongJ,WangX,ZhuX,YanJ,WeiY,JinH,ZhangW,WenL,TangFuchou*,QiaoJ*.DNAmethylationandchromatinaccessibilityprofilingofmouseandhumanfetalgermcells.CellResearch,2017,27:165-183(*:Co-correspondingauthors).

11.YangL,MaZ,CaoC,ZhangY,WuX,LeeR,HuB,WenL,GeH,HuangY*,LaoK*,TangFuchou*.MR-seq:measuringasinglecell’stranscriptomerepeatedlybyRNA-seq.ScienceBulletin,2017,62:391-398(*:Co-correspondingauthors).

12.ZhouF,LiX,WangW,ZhuP,ZhouJ,HeW,DingM,XiongF,ZhengX,LiZ,NiY,MuX,WenL,ChengT,LanY,YuanW*,TangFuchou*,LiuB*.Tracinghaematopoieticstemcellformationatsingle-cellresolution.Nature,2016,533:487-492(*:Co-correspondingauthors).

13.DangY,YanL,HuB,FanX,RenY,LiR,LianY,YanJ,LiQ,ZhangY,LiM,RenX,HuangJ,WuY,LiuP,WenL,ZhangC,HuangY*,TangFuchou*,QiaoJ*.TracingtheexpressionofcircularRNAsinhumanpre-implantationembryos.GenomeBiology,2016,17:130(*:Co-correspondingauthors).

14.WenL*,TangFuchou*.Single-cellsequencinginstemcellbiology.GenomeBiology,2016,17:71(Review)(*:Co-correspondingauthors).

15.HouY,GuoH,CaoC,LiX,HuB,ZhuP,WuX,WenL,TangFuchou*,HuangY*,PengJ*.Single-celltripleomicssequencingrevealsgenetic,epigenetic,andtranscriptomicheterogeneityinhepatocellularcarcinomas.CellResearch,2016,26:304-319(*:Co-correspondingauthors).

16.PanH,GuanD,LiuX,LiJ,WangL,WuJ,ZhouJ,ZhangW,RenR,ZhangW,LiY,YangJ,HaoY,YuanT,YuanG,WangH,JuZ,MaoZ,LiJ,QuJ*,TangFuchou*,LiuGH*.SIRT6safeguardshumanmesenchymalstemcellsfromoxidativestressbycoactivatingNRF2.CellResearch,2016,26:190-205(*:Co-correspondingauthors).

17.YanL,GuoH,HuB,LiR,YongJ,ZhaoY,ZhiX,FanX,GuoF,WangX,WangW,WeiY,WangY,WenL,QiaoJ*,TangFuchou*.Epigenomiclandscapeofhumanfetalbrain,heart,andliver.JournalofBiologicalChemistry,2016,291:4386-4398(*:Co-correspondingauthors).

18.WenL*,TangFuchou*,Howtocatchrarecelltypes.Nature,2015,525:197-198(Preview)(*:Co-correspondingauthors).

19.GuoF,YanL,GuoH,LiL,HuB,ZhaoY,YongJ,HuY,WangX,WeiY,WangW,LiR,YanJ,ZhiX,ZhangY,JinH,ZhangW,HouY,ZhuP,LiJ,ZhangL,LiuS,RenY,ZhuX,WenL,GaoYQ,TangFuchou*,QiaoJ*.ThetranscriptomeandDNAmethylomelandscapesofhumanprimordialgermcells.Cell,2015,161:1437-1452(*:Co-correspondingauthors).

20.ZhangW,LiJ,SuzukiK,QuJ,WangP,ZhouJ,LiuX,RenR,XuX,OcampoA,YuanT,YangJ,LiY,ShiL,GuanD,PanH,DuanS,DingZ,LiM,YiF,BaiR,WangY,ChenC,YangF,LiX,WangZ,AizawaE,GoeblA,SoligallaRD,ReddyP,EstebanCR,TangFuchou*,LiuGH*,BelmonteJC*.AWernersyndromestemcellmodelunveilsheterochromatinalterationsasadriverofhumanaging.Science,2015,348:1160-1163(*:Co-correspondingauthors).

21.WenL*,TangFuchou*,ChartingaMapthroughtheCellularReprogrammingLandscape.CellStemCell,2015,16:215-216(Preview)(*:Co-correspondingauthors).

22.YanL,HuangL,XuL,HuangJ,MaF,ZhuX,TangY,LiuM,LianY,LiuP,LiR,LuS,TangFuchou*,QiaoJ*,XieXS*.Livebirthsaftersimultaneousavoidanceofmonogenicdiseasesandchromosomeabnormalitybynext-generationsequencingwithlinkageanalyses.ProcNatlAcadSciUSA,2015,112:15964-15969(*:Co-correspondingauthors).

23.DuanS,YuanG,LiuX,RenR,LiJ,ZhangW,WuJ,XuX,FuL,LiY,YangJ,ZhangW,BaiR,YiF,SuzukiK,GaoH,EstebanCR,ZhangC,IzpisuaBelmonteJC,ChenZ,WangX,JiangT,QuJ*,TangFuchou*,LiuGH*.PTENdeficiencyreprogrammeshumanneuralstemcellstowardsaglioblastomastemcell-likephenotype.NatureCommunications,2015,6:10068(*:Co-correspondingauthors).

24.WenL,LiJ,GuoH,LiuX,ZhengS,ZhangD,ZhuW,QuJ,GuoL,DuD,JinX,ZhangY,GaoY,ShenJ,GeH,TangFuchou*,HuangY*,PengJ*.Genome-scaledetectionofhypermethylatedCpGislandsincirculatingcell-freeDNAofhepatocellularcarcinomapatients.CellResearch,2015,25:1250-1264(*:Co-correspondingauthors).

25.FanX,ZhangX,WuX,GuoH,HuY,TangFuchou*,HuangY*.Single-cellRNA-seqtranscriptomeanalysisoflinearandcircularRNAsinmousepreimplantationembryos.GenomeBiology,2015,16:148(*:Co-correspondingauthors)

26.GuoH,ZhuP,GuoF,LiX,WuX,FanX,WenL*,TangFuchou*.ProfilingDNAmethylomelandscapesofmammaliancellswithsingle-cellreduced-representationbisulfitesequencing.NatureProtocols,2015,10:645-659(*:Co-correspondingauthors).

27.WuY,ZhouH,FanX,ZhangY,ZhangM,WangY,XieZ,BaiM,YinQ,LiangD,TangW,LiaoJ,ZhouC,LiuW,ZhuP,GuoH,PanH,WuC,ShiH,WuL*,TangFuchou*,LiJ,*.CorrectionofaGeneticDiseasebyCRISPR-Cas9-MediatedGeneEditinginMouseSpermatogonialStemCells.CellResearch,2015,25:67-79(*:Co-correspondingauthors).

28.ShenJ,JiangD,FuY,WuX,GuoH,FengB,PangY,StreetsAM,TangFuchou*,HuangY*.H3K4me3epigenomiclandscapederivedfromChIP-Seqof1000mouseearlyembryoniccells.CellResearch,2015,25:143-147(*:Co-correspondingauthors).

29.GuoF,LiX,LiangD,LiT,ZhuP,GuoH,WuX,WenL,GuTP,HuB,WalshCP,LiJ*,TangFuchou*,XuGL*.ActiveandPAssiveDemethylationofMaleandFemalePronuclearDNAintheMammalianZygote.CellStemCell,2014,15:447-458(*:Co-correspondingauthors).

30.GuoH,ZhuP,YanL,LiR,HuB,LianY,YanJ,RenX,LinS,LiJ,JinX,ShiX,LiuP,WangX,WangW,WeiY,LiX,GuoF,WuX,FanX,YongJ,WenL,XieSX,TangFuchou*,QiaoJ*.TheDNAmethylationlandscapeofhumanearlyembryos.Nature,2014,511:606-610(*:Co-correspondingauthors).

31.WenL,TangFuchou*,ReconstructingComplexTissuesfromSingle-CellAnalyses.Cell,2014,157:771-773(*:Correspondingauthor).

32.WenL,LiX,YanL,TanY,LiR,ZhaoY,WangY,XieJ,ZhangY,SongC,YuM,LiuX,ZhuP,LiX,HouY,GuoH,WuX,HeC*,LiR*,TangFuchou*,QiaoJ*.Whole-genomeanalysisof5-hydroxymethylcytosineand5-methylcytosineatbaseresolutioninthehumanbrain.GenomeBiology,2014,15:R49(*:Co-correspondingauthors).

33.StreetsAM,ZhangX,CaoC,PangY,WuX,XiongL,YangL,FuY,ZhaoL*,TangFuchou*,HuangY*.Microfluidicsingle-cellwhole-transcriptomesequencing.ProcNatlAcadSciUSA,2014,111:7048-7053(*:Co-correspondingauthors).

34.HouY,FanW,YanL,LiR,LianY,HuangJ,LiJ,XuL,TangFuchou*,XieXS*,QiaoJ*.GenomeAnalysesofSingleHumanOocytes.Cell,2013,155:1492-1506(*:Co-correspondingauthors).

35.GuoH,ZhuP,WuX,LiX,WenL,TangFuchou*.Single-cellmethylomelandscapesofmouseembryonicstemcellsandearlyembryosanalyzedusingreducedrepresentationbisulfitesequencing.GenomeResearch,2013,23:2126-2135(*:Correspondingauthor).

36.YanL,YangM,GuoH,YangL,WuJ,LiR,LiuP,LianY,ZhengX,YanJ,HuangJ,LiM,WuX,WenL,LaoK,LiR*,QiaoJ*,TangFuchou*.Single-cellRNA-Seqprofilingofhumanpreimplantationembryosandembryonicstemcells.NatureStructural&MolecularBiology,2013,20:1131-1139(*:Co-correspondingauthors).

37.GanH,WenL,LiaoS,LinX,MaT,LiuJ,SongCX,WangM,HeC,HanC*,TangFuchou*.Dynamicsof5-hydroxymethylcytosineduringmousespermatogenesis.NatureCommunications,2013,4:1995(*:Co-correspondingauthors).

38.HuX,ZhangL,MaoSQ,LiZ,ChenJ,ZhangRR,WuHP,GaoJ,GuoF,LiuW,XuGF,DaiHQ,ShiYG,LiX,HuB,TangF.,PeiD,XuGL.TetandTDGMediateDNADemethylationEssentialforMesenchymal-to-EpithelialTransitioninSomaticCellReprogramming.CellStemCell,2014,14:512-522.

39.GraboleN,TischlerJ,HackettJA,KimS,TangF.,LeitchHG,MagnúsdóttirE,SuraniMA.Prdm14promotesgermlinefateandnaivepluripotencybyrepressingFGFsignallingandDNAmethylation.EMBOReports,2013,14:629-637.

40.ZhangRR,CuiQY,MuraiK,LimYC,SmithZD,JinS,YeP,RosaL,LeeYK,WuHP,LiuW,XuZM,YangL,DingYQ,TangF.MeissnerA,DingC,ShiY,XuGL.Tet1RegulatesAdultHippocampalNeurogenesisandCognition.CellStemCell,2013,13:237-245.

41.MagnúsdóttirE,DietmannS,MurakamiK,GünesdoganU,TangF.,BaoS,DiamantiE,LaoK,GottgensB,SuraniMA.Atripartitetranscriptionfactornetworkregulatesprimordialgermcellspecificationinmice.NatureCellBiology,2013,15:905-915.

42.LuS,ZongC,FanW,YangM,LiJ,ChapmanAR,ZhuP,HuX,XuL,YanL,BaiF,QiaoJ,TangF.,LiR,XieXS.Probingmeioticrecombinationandaneuploidyofsinglespermcellsbywhole-genomesequencing,Science,2012,338:1627-1630.

43.BaoS,LeitchHG,GillichA,NicholsJ,TangF.,KimS,LeeC,ZwakaT,LiX,SuraniMA,Thegermcelldeterminantblimp1isnotrequiredforderivationofpluripotentstemcells.CellStemCell,2012,11:110-117.

44.TangF,LaoK,SuraniMA.Developmentandapplicationsofsingle-celltranscriptomeanalysis.NatureMethods,2011,8:S6-S11(Review).

45.TangF,BarbacioruC,BaoS,LeeC,NordmanE,WangX,LaoK,SuraniMA.TracingtheDerivationofEmbryonicStemCellsfromtheInnerCellMAssbySingle-CellRNA-SeqAnalysis.CellStemCell,2010,6:468–478.

46.TangFuchou*.SmallRNAsinmammaliangermline:tinyforimmortal.Differentiation,2010,79:141-146(Review)(*:Correspondingauthor)

47.TangF,BarbacioruC,NordmanE,LiB,XuN,BashkirovVI,LaoK,SuraniMA.RNA-Seqanalysistocapturethetranscriptomelandscapeofasinglecell.NatureProtocols,2010,5:516-535.

48.BaoS*,TangF*,LiX,HayashiK,GillichA,LaoK,SuraniMA.Epigeneticreversionofpostimplantationepiblasttopluripotentembryonicstemcells.Nature,2009,461:1292-1295(*:co-firstauthors).

49.TangF*,BarbacioruC*,WangY,NordmanE,LeeC,XuN,WangX,BodeauJ,TuchBB,SiddiquiA,LaoK,SuraniMA.mRNA-Seqwholetranscriptomeanalysisofasinglecell.NatureMethods,2009,6:377-382(*:co-firstauthors).

50.HayashiK,LopesSM,TangF,SuraniMA.Dynamicequilibriumandheterogeneityofmousepluripotentstemcellswithdistinctfunctionalandepigeneticstates.CellStemCell,2008,3:391-401.

51.TangF*,KanedaM*,O`CarrollD,HajkovaP,BartonSC,SunYA,LeeC,TarakhovskyA,LaoK,SuraniMA.MaternalmicroRNAsareessentialformousezygoticdevelopment.Genes&Development,2007,21:644-648(*:co-firstauthors).

52.TangF,HajkovaP,BartonSC,O`CarrollD,LeeC,LaoK,SuraniMA.220-plexmicroRNAexpressionprofileofasinglecell.NatureProtocols,2006,1:1154-1159.

53.TangF,HajkovaP,BartonSC,LaoK,SuraniMA.MicroRNAexpressionprofilingofsinglewholeembryonicstemcells.NucleicAcidsResearch,2006,34:e9.

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